Macrolide antibiotics and cystic fibrosis.
نویسنده
چکیده
منابع مشابه
Synergistic activities of macrolide antibiotics against Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans isolated from patients with cystic fibrosis.
Azithromycin and clarithromycin were paired with other antibiotics to test synergistic activity against 300 multidrug-resistant pathogens isolated from cystic fibrosis (CF) patients. Clarithromycin-tobramycin was most active against Pseudomonas aeruginosa and inhibited 58% of strains. Azithromycin-trimethoprim-sulfamethoxazole, azithromycin-ceftazidime, and azithromycin-doxycycline or azithromy...
متن کاملMacrolide antibiotic therapy in patients with cystic fibrosis.
This summary of the current knowledge of macrolide therapy serves as an example of recent progress in the therapeutic approach to treating patients with cystic fibrosis (CF). The benefit of macrolides in the treatment of patients with diffuse panbronchiolitis and Pseudomonas aeruginosa infections, as seen in Japan, was the rational behind trials in patients with CF. Thus far, the majority of re...
متن کاملTissue reparative effects of macrolide antibiotics in chronic inflammatory sinopulmonary diseases.
It is well established that macrolide antibiotics are efficacious in treating sinopulmonary infections in humans. However, a growing body of experimental and clinical evidence indicates that they also express distinct salutary effects that promote and sustain the reparative process in the chronically inflamed upper and lower respiratory tract. Unlike the anti-infective properties, these distinc...
متن کاملMacrolide antibiotics in diffuse panbronchiolitis and in cystic fibrosis.
I share the interest shown by EVERARD et al. [1] in the use of macrolide antibiotics in cystic fibrosis (CF). Some patients with chronic Pseudomonas colonization do appear to improve when given prolonged courses of azithromycin, and the possibility that this is due to an anti-inflammatory rather than an antibacterial effect is supported by the findings of MOLINARI et al. [2] that subinhibitory ...
متن کاملClarithromycin suppresses airway hyperresponsiveness and inflammation in mouse models of asthma.
Macrolide antibiotics, a class of potent antimicrobials, also possess immunomodulatory/anti-inflammatory properties. These properties are considered fundamental for the efficacy of macrolide antibiotics in the treatment of diffuse panbronchiolitis and cystic fibrosis. In patients with asthma, macrolide antibiotics have been reported to reduce airway hyperresponsiveness and improve pulmonary fun...
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عنوان ژورنال:
- Thorax
دوره 57 3 شماره
صفحات -
تاریخ انتشار 2002